Studies on antivenom activity of 50% methanol extract of Cissus multistriata against Naja nigricollis venom

The extract of Cissus multistriata has been used to cure many diseases. In this work, fifty percent methanol leaf extract of the plant was studied for its antivenom activity against the crude venom of Naja nigricollis. Eleven physiologic parameters which include total plasma protein, albumin, creatinine, urea, uric acid, sodium, potassium, chloride, alanine amino transferase, aspartate amino transferase and alkaline phosphatase were measured in the thirty-one albino rats used in the study to monitor the potency or otherwise of the extract against the snake venom. It was discovered that fifty percent methanol leaf extract of Cissus multistriata has antivenom effect against N. nigricollis venom.

Key words: N. nigricollis, Cissus multistriata, antivenom, extract.