Anti-inflammatory Activity Researches on Tripleurospermum parviflorum (Willd.) Pobed. and Tripleurospermum tenuifolium (Kit.)

Tripleurospermum species have been used for the treatment of inflammatory diseases in Turkish traditional medicine. The present study was designed to evaluate the anti-inflammatory activity potential and fatty acid composition of the extracts prepared from the aerial parts of Tripleurospermum parviflorum (Willd.) Pobed. and T. tenuifolium (Kit.) Anti-inflammatory activity was assessed by using carrageenan-, and serotonin- induced hind paw edema and acetic acid-induced increase in capillary permeability models. EtOAc extracts of T. parviflorum and T. tenuifolium exerted remarkable inhibitory effect in the carrageenan- induced hind paw edema model with the values of 27.4 and 24.4%, respectively. The EtOAc extracts of T. parviflorum and T. tenuifolium also demonstrated notable anti-inflammatory activity on acetic acid-induced increase in capillary permeability model with the significant inhibition values of 29.3 and 26.3%, respectively at 200 mg/kg dose. The fatty acid compositions of the plants were investigated by gas chromatography (GC). Generally, C 16:0 palmitic acid and C 18:2 linoleic acid were found to be the major fatty acids in two species. Saturated fatty acids (SFAs) were found in higher amounts than monosaturated and polyunsaturated fatty acids. SFAs were determined as 58.68 and 63.15% in T. parviflorum and T. tenuifolium, respectively. The high content of linoleic acid and palmitic acid may be primarily responsible for significant anti-inflammatory activity. The present study confirms the anti-inflammatory activity of T. parviflorum and T. tenuifolium.