Inhibitory effect of Solanum tuberosum L. var. Vitelotte extract in the development of 2,4-Dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice

Solanum tuberosum L. var. Vitelotte (SV) contains various polyphenols and anthocyanins that are believed to have antioxidant and anti-inflammatory activity. The objective of this study is to evaluate the effects of oral administration of SV extract on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) in NC/Nga mice.

The DNCB-induced NC/Nga mice were used for treatment with SV extract (75, 150, and 300 mg/kg) for 4 weeks. Oral administration of SV extract alleviated the AD-like skin symptoms, scratching behaviors and ear thickness. Oral administration of SV extract reduced the level of IgE and IgG1, whereas it increased the level of IgG2a in a dose-dependent manner [1]. The calculated IgG1/IgG2a ratio for each mouse revealed that the SV extract also significantly reduced the Th2/Th1 ratio, IL-4 and IL-13 (as Th2 cytokines), IFN-gamma and IL-12 (as a Th1 cytokines) in spleens [1]. In addition, it significantly decreased gene expression such as eotaxin-1, CCR3, IL-4, IL-5, IFN-gamma, IL-12, and TARC, in AD-like lesions. Histological analyses demonstrated decreased thickening of the epidermis as well as dermal infiltration by inflammatory cells [2].

These results suggest that SV extract can be considered as candidate for therapeutic agents for the treatment of AD via an immune-regulative effect.

Reference:

[1] Kim, M.J. et al. (2012) Evid-based Compl. Alt. Epub 2012 Oct 23.

[2] Choi, J.H. et al. (2012) Food. Chem. Toxicol. 50: 2923 – 2929.