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DOI: 10.1055/s-0033-1351962
Lesion Inhibition Index of Pterodon pubescens Benth. Crude Extracts Evaluated On Ethanol Induced Ulcer Models In Rats
Inflammation is a natural response to tissue infection or injury. Nevertheless, chronic inflammation has an adverse effect on the body, such as function loss of the affected tissue and thus decreases life quality of individuals. Glucocorticoids and NSAIDs are nowadays the main family of drugs used to treat inflammation although they frequently expose the gastric mucosa leading to gastric ulcer development and other side effects. Previous studies have demonstrated the anti-inflammatory activity of vouacapans, diterpene furans isolated from P. pubescens Benth species. With the intention of investigating possible side effects produced by this species this study had the aim to evaluate the antiulcerogenic activity of crude dicloromethane (Pp) and aqueous (Ppa) extracts on gastric ulcer model induced by ethanol. The antiulcerogenic effect of Ppa and Pp extract of P. pubescens were evaluated in ethanol induced gastric ulcer model in Wistar rats. The extracts were administered orally at three different doses of 30, 100 and 300 mg/kg. The ulcer score was the parameter measured in this model. The results revealed significant decrease in the average number of ulcers at 100 and 300 mg/kg doses for Ppa (80% and 90% respectively ANOVA p < 0.001). Whereas Pp at 10 and 30 mg/kg doses (20% e 80% respectively ANOVA p < 0.05) inhibited ulceration index. These results showed that the anti-inflammatory activity of P. pubescens extract has no relationship with COX inhibition or may have some selectivity for COX II. However further studies are needed to assess the antiulcerogenic mechanism of action of theses extracts.