Planta Med 2013; 79 - PA31
DOI: 10.1055/s-0033-1351935

Alpha amylase inhibitory and Antioxidant activity of Padina boergesenii (Allander and Kraft) from Persian Gulf

P Permeh 1, A Gohari 2, S Saeidnia 2, S Jamili 3, S Permeh 4, P Ghavam Mostafavi 3
  • 1Department of Marine Biology, Faculty of Marine Science and Technology, Science and Research Branch, Islamic Azad University (IAU), Tehran, Iran
  • 2Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  • 3Department of Marine Biology, Faculty of Marine Science and Technology, Science and Research Branch, Islamic Azad University (IAU), Tehran, Iran.
  • 4Mining department of Amirkabir University of Technology, Tehran, Iran

Among marine organisms, algae are a large and diverse group of organisms from which a wide range of secondary metabolites have been isolated. A number of these compounds possess biological activity such as toxicity, antibacterial, antifungal, antiviral, anti-tumor, anti diabetic and other specific activities (1 – 3). Padina boergesenii (Allander and Kraft) is the most abundant algae distributed in the Persian Gulf. In this study the Ferric Reducing Ability of Plasma (FRAP) activity and hypoglycemic effect was determined. methanol extract from P. boergesenii showed a considerable antioxidant effect 145.5µ mol/lit (concentration of extract used = 20 mg/ml)and also higher inhibitory activity than the positive control against α-amylase. The IC50 value of P. boergesenii methanolic extract againstα-amylase was 0.29 mg/ml. (Concentrations: 0.05, 0.1, 0.25, 0.5 mg/ml). Acarbose (IC50 = 0.53 mg/ml) was used as a positive control. Antioxidant and antidiabetic activity might be due to the presence of carotenoid, sterol, fucoxanthin, active phenolic compounds, and monoterpenes in the extracts.

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