Planta Med 2013; 79 - PA16
DOI: 10.1055/s-0033-1351920

Inhibitory effect of active peptide from oyster hydrolysate on Angiotensin-I Converting Enzyme (ACE)

S Kim 1, C Bang 1, A Kim 2, J Ha 2, Y Choi 3, S Choung 1
  • 1Department of Preventive Pharmacy and Toxicology, College of Pharmacy, Kyung Hee University, Seoul 130 – 701, Korea
  • 2Department of Pharmaceutical Engineering, College of Medical & Life Science, Silla University, Busan, Korea
  • 3Department of Marine Processing, Kyungsang National University, Tongyoung, Korea

Heart disease is the leading causes of death in many countries and high blood pressure has been one of the main risk factors for it. [1] Angiotensin-I Converting Enzyme (ACE) has an important physiological role in the regulation of blood pressure. [2]

The objective of this research was to study the ACE inhibition effect of oyster hydrolysates fraction (OH) and isolate active peptide. We investigated the effects of oyster hydrolysates fraction and active peptide on the blood pressure levels in stroke-prone spontaneously hypertensive rats (SHRSPs). Thirteen-week-old SHRSPs were assigned to four groups; the control group, positive control group (Val-Tyr), OH group, and isolated active peptide groups. Administration of Val-Tyr (50 µg/kg), OH (100 mg/kg) and isolated active peptide (50 µg/kg) decreased the maximum blood pressure at 9 (29.7%), 9 (37.9%) and 6 hr (12%), respectively. The blood pressure levels in treated group were maintained until 24 hr after administration. Furthermore, we measured ACE activity in the serum, aorta and kidney. In the serum and aorta, the SHRSPs showed higher ACE activity than the treated groups.

These results suggest that OH and the isolated active peptide can be considered as a potential source for antihypertensive functional foods or drugs.

References:

[1] James R.S. et al. (2001) Hypertension 37: 1053 – 1059.

[2] Tetsuya S. et al. (2004) Hypertension 43: 1003 – 1010.