Planta Med 2013; 79 - WS24
DOI: 10.1055/s-0033-1351825

QBD in process design for phytoextracts

M Tegtmeier 1, J Strube 2, S Both 2, H Hagels 3
  • 1Schaper&Bruemmer Pharma GmbH & Co KG, Salzgitter (D-38259), Germany
  • 2Clausthal University of Technology (Institute for Separation and Process Technology), Clausthal-Zellerfeld (D-38638), Germany
  • 3Boehringer Ingelheim Pharma GmbH & Co. KG (Phyto Center), Ingelheim (D-55216), Germany

In the current time of increasing costs for mineral resources, plants come back into focus of even the chemical industry as their use can assure sustainability and environmental compatibility. Plant constituents are used to substitute basic chemicals of petrochemical origin more and more. The first step for preparing the desired natural constituents is always an extraction. [1] Today the central aim for research and development of extraction procedures are safe, efficient and successful processes. Their use guarantees the necessary high quality and attractive economic efficiency in the use of plant extracts. In recent years, process design as well as optimization of existing processes is supported by theoretical modeling the unit operations. Therefore, model parameters should be determined in lab scale [2].

On the other hand, new principles in the research are generated, which allow a rapid screening of possible conditions for extraction in the view of basic processes, solvents, temperatures and pressures. So also the complex character of plant extracts is considered, which is determined by the multicomponent mixture of groups constituents of interest and also the side-fractions. The extraction process has to guarantee that side-fractions are not critical in the subsequent use of the plant extract. Selective extractions should therefore assure that problematic fractions are not co-extracted [3].


[1] Phytoextrakte +Okt+2012.pdf

[2] Josch, J.P. et al, Food and Nutricion Science, 3 (6): 2012

[3] Tegtmeier, M., Chemie Ingenieur Technik 84 (6): 1 – 4. 2012