Chemical Constituents from Trichilia connaroides and Their Nitric Oxide Production and α-Glucosidase Inhibitory Activities

Abstract

Phytochemical investigation of the stem and bark of Trichilia connaroides led to the isolation of eight new nortriterpenoids (1–8), along with fifteen known compounds (9–23). Their structures were established based on extensive spectroscopic analysis. The absolute configuration of 2 was confirmed by X-ray crystallographic study. The nitric oxide production and α-glucosidase inhibitory effects for these isolates were evaluated: moderate to strong nitric oxide production inhibitory activities were found for 5, 6, and 11–15, with IC₅₀ values ranging from 7.5 to 26.3 µM; marked α-glucosidase inhibitory effects were observed for 22 and 23, with IC₅₀ values of 2.3 and 0.4 µM, respectively.

Key words

Trichilia connaroides - Meliaceae - nortriterpenoids - pregnanes - lignans - NO production inhibition - α-glucosidase inhibition

• References

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