Triterpenoids and Steroids with Cytotoxic Activity from
                        Emmenopterys henryi

Xing-De Wu; Juan He; Xing-Yao Li; Liao-Bin Dong; Xun Gong; Xiu Gao; Liu-Dong Song; Yan Li; Li-Yan Peng; Qin-Shi Zhao

doi:10.1055/s-0033-1350645

Planta Medica, Inhaltsverzeichnis

Planta Med 2013; 79(14): 1356-1361
DOI: 10.1055/s-0033-1350645

Natural Product Chemistry

Original Papers

Georg Thieme Verlag KG Stuttgart · New York

Triterpenoids and Steroids with Cytotoxic Activity from Emmenopterys henryi

Authors

Xing-De Wu

¹State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
Juan He

¹State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
Xing-Yao Li

¹State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
Liao-Bin Dong

¹State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
Xun Gong

¹State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
Xiu Gao

¹State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
Liu-Dong Song

²School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, P. R. China
Yan Li

¹State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
Li-Yan Peng

¹State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
Qin-Shi Zhao

¹State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China

Abstract

Two new ursane-type triterpenoids, 3β,19α,23-trihydroxyurs-12-en-24-al-28-oic acid (1) and 3β,19α,24-trihydroxy-23-norurs-12-en-28-oic acid (2), two new pregnane derivatives, 3β,12β-dihydroxy-5α-pregnane-14,16-dien-20-one (9) and 12β-hydroxy-5α-pregnane-14,16-dien-3,20-dione (10), and eight known compounds were isolated from the twigs and leaves of Emmenopterys henryi. The structures of the new compounds were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR experiments. Compounds 4, 11, and 12 showed cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines with IC₅₀ values in the range of 3.11–20.12 µM.

Key words

Emmenopterys henryi - Rubiaceae - ursane-type triterpenoids - pregnane derivatives - cytotoxic activity

Volltext

Referenzen

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