Planta Med 2013; 79 - PN96
DOI: 10.1055/s-0033-1348777

Two New Secondary Metabolites Isolated from Dodonaea Viscosa LINN. Growing in Egypt

AE Mostafa 1, 4, AA El-Hela 4, AEI Mohammad 4, SJ Cutler 3 SA Ross 1, 2*
  • 1National Center for Natural Products Research
  • 2Department of Pharmacognosy
  • 3Department of Medicinal Chemistry, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
  • 4Department of Pharmacognosy, Faculty of Pharmacy, University of Al-Azhar, Cairo 11371, Egypt

Bioassay guided fractionation of the ethanolic extract of Dodonaea viscosa (Sapindaceae) resulted in the isolation of two new compounds identified as Clerodane diterpenoid (1), 1-L-1-O-methyl-2-acetyl-3-P-Z-coumaroyl-myo-inositol (2), alongside with ten known compounds (3 – 12). The structures of the isolated compounds were elucidated by using NMR spectroscopy and HRESIMS. Isolated compounds were evaluated for their antimalarial, antileishmanial, antifungal and antimicrobial activities. Compound (5) showed good antifungal activity against Cryptococcus neoformans with an IC50 value of 6.11 µg/mL. Compounds (10 and 12) showed moderate antileishmanial activity against Leishmania donovani with an IC50 value of 16.60 and 19.06 µg/mL respectively.