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Pentalinonsterol Alters Fatty Acid Composition of the Lipids in the Promastigotes of Leishmania
The ability of pentalinonsterol, a new antileishmanial agent original isolated from Pentalinon andrieuxii, in altering fatty acid composition of the lipid in the promastigotes of Leishmania was evaluated. Synthesized pentalinonsterol caused significant decreases in the levels of certain saturated fatty acids and unsaturated fatty acids in the promastigotes. However, the levels of omega-3 fatty acids such as the eicosapentaenoic and docosahexaenoic acids were significantly elevated. This study reveals that pentalinonsterol differentially altered the fatty acid composition in the lipids of promastigotes of Leishmania suggesting the membrane-altering properties and lipid metabolism-modulating actions of pentalinonsterol in the promastigotes of Leishmania.