Novel Monoterpenoid from Cornus Controversa and their Biological Activities
Five new monoterpenoid iridolactones, cornosides A – E (1 – 5) have been isolated from Cornus controversa. The structures of 1 – 5 were elucidated on the basis of extensive spectroscopic analysis. Cornoside A (1) is the first natural cis-fused tricyclic dilactone iridoid possessing a 4S-methyl-1H-2,6-dioxahexahydorcyclopent [c, d]indene-1,7 (2 H)-dione ring system. Cornoside B (2) exhibited potent liver X receptor (LXR) agonistic activity.
Acknowledgment. This research was financially supported by the National Institutes of Health Grants (P41GM079597 and P01GM085354), the NCCAM RO1AT007318, an NIH research facilities improvement grant C06 RR-14503 – 01, and thanks the Scientific Research Program Funded by Shaanxi Provincial Education Department (2010JK749).