Planta Med 2013; 79 - PN69
DOI: 10.1055/s-0033-1348750

Novel Monoterpenoid from Cornus Controversa and their Biological Activities

Y He 1, 2, G Ma 3, J Peng 4, MT Hamann 3, LM West 2
  • 1Department of Applied Chemistry, Xi'an University of Technology, Xi'an, Shaanxi 710054, P. R. China
  • 2Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida 33431, USA
  • 3Department of Pharmacognosy, School of Pharmacy, University of Mississippi, Mississippi 38677, USA
  • 4Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA

Five new monoterpenoid iridolactones, cornosides A – E (1 – 5) have been isolated from Cornus controversa. The structures of 1 – 5 were elucidated on the basis of extensive spectroscopic analysis. Cornoside A (1) is the first natural cis-fused tricyclic dilactone iridoid possessing a 4S-methyl-1H-2,6-dioxahexahydorcyclopent [c, d]indene-1,7 (2 H)-dione ring system. Cornoside B (2) exhibited potent liver X receptor (LXR) agonistic activity.

Acknowledgment. This research was financially supported by the National Institutes of Health Grants (P41GM079597 and P01GM085354), the NCCAM RO1AT007318, an NIH research facilities improvement grant C06 RR-14503 – 01, and thanks the Scientific Research Program Funded by Shaanxi Provincial Education Department (2010JK749).