Planta Med 2013; 79 - PN54
DOI: 10.1055/s-0033-1348735

Galloylated Flavonol Glycosides from Leaves of Calliandra tergemina with Antibacterial Activities against Methicillin-Resistant Staphylococcus aureus (MRSA)

EW Ling Chan 1, JK Goh 1, SM Lee 1, AI Gray 2, JO Igoli 2
  • 1School of Science, Monash University Sunway Campus, Jalan Lagoon Selatan, 46150 Bandar Sunway, Selangor Malaysia
  • 2Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, The John Arbuthnott Building, 161 Cathedral Street, G4 0RE Glasgow, Scotland

Three galloylated flavonol glycosides 1 – 3, together with five known flavonol glycosides 4 – 8 were isolated from the active leaves extract of Calliandra tergemina. Their structures and molecular formula were established using spectroscopic analysis and their anti-MRSA (methicillin-resistant Staphylococcus aureus) activities were evaluated by broth microdilution. The isolation of compounds 1 – 8, together with the structural-activity relationship of these flavonol glycosides, based on their anti-MRSA activities, will be presented.