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Four New Alkaloids from Delphinium chrysotrichum
Delphinium chrysotrichum has been used in Tibetan folk medicine for the treatments of rheumatism and neuralgia for a long time in China. Bioassay-guided fractionation of the whole herbs of D. chrysotrichum resulted in the isolation of one new diterpene alkaloid delphatisine D (1) and three new norditerpenoid alkaloids chrysotrichumine A (2), chrysotrichumine B (3), chrysotrichumine C (4), along with 9 known compounds, 3β,6α-dihydroxysclareolide (5), delcorine (6), delbrusine (7), delsemine B (8), delavaine A (9), lycoctonine (10), davidisine B (11), delpheline (12), delphatisine A (13). The chemical structures of the four new compounds (1 – 4) were elucidated on the basis of extensive 1D and 2D NMR and HR-ESI-MS data. Compound 5 is the first sesquiterpenoid isolated from genus Delphinium. The cytotoxicity against breast cancer cell line MCF-7 and MDA-MB-231 were evaluated.
Acknowledgment. This research was supported by National Institutes of Health grants (P41GM079597 and P01GM085354) and by the Scientific Research Program Funded by Shaanxi Provincial Education Department in China (2010JK749).