Planta Med 2013; 79 - PN48
DOI: 10.1055/s-0033-1348729

Evaluation of Bitterness-Masking Agents from Solidago canadensis (Canada Goldenrod)

Y Deng 1, JN Fletcher 1, J Li 1, L Pan 1, MA Vincent 2, JP Slack 3, TS McCluskey 3, AD Kinghorn 1, Z Jia 3
  • 1College of Pharmacy, Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
  • 2Department of Botany, Miami University, Oxford, OH 45056, USA
  • 3Givaudan Flavors Corporation, Cincinnati, OH 45216, USA

In an in vitro screen of plants native to Ohio against the bitterness receptor hTAS2R31, one new labdane diterpenoid (1), and eight known compounds, including two labdane diterpenoids (2 and 3), three clerodane diterpenoids (4 – 6), an abietane diterpenoid (7), a flavonoid (8), and a triterpenoid (9), were isolated and identified from the chloroform-soluble extract of Solidago canadensis (Asteraceae). Among these compounds, 3-acetoxycopalic acid (2) was found to be the first member of the labdane diterpene class shown to have inhibitory activity against hTAS2R31 activation (IC50 = 8µM).