Planta Med 2013; 79 - PN41
DOI: 10.1055/s-0033-1348722

Cytotoxic Flavonoids from the Flower Buds of Rosa rugosa

QF Hu 1, 2, B Zhou 1, 3, JM Huang 2, 4, ZY Jiang 1, XZ Huang 1, LY Yang 1, XM Gao 1, GY Yang 1, 3, CT Che 2
  • 1Key Laboratory of Chemistry in Ethnic Medicinal Resources, Yunnan Univ. of Nationalities, Kunming 650031, People's Republic of China
  • 2Dept. of Medicinal Chemistry and Pharmacognosy and WHO Collaborating Center for Traditional Medicine, College of Pharmacy, Univ. of Illinois at Chicago, Chicago, Illinois 60612
  • 3Key Laboratory of Tobacco Chemistry, Yunnan Academy of Tobacco Science, Kunming 650106, P.R. China
  • 4Dept. of Pharmacognosy, School of Pharmacy, Fudan Univ., Shanghai 201203, P.R. China

Eight new flavonoids, rugosaflavonoids A-H (1-8), together with eleven known compounds, were isolated from the flower buds of Rosa rugosa. All structures were determined by spectroscopic methods. 1 is a flavone possessing a unique 8,9-seco skeleton. 2 displayed cytotoxicity against NB4, SHSY5Y and MCF7 cells with IC50 values of 2.2, 2.5 and 2.3 µM, respectively; and 3 was toxic to A549 and MCF7 cells with IC50 values of 1.2 and 2.8 µM, respectively.