Planta Med 2013; 79 - PN33
DOI: 10.1055/s-0033-1348714

Chalcone Oligomers from Brackenridgea zanguebarica

HH Issa 1, 2, N Abe 1, Z Ali 1, IA Khan 1, 3
  • 1National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, 38677, USA
  • 2Department of Chemistry, College of Natural Sciences and Mathematics, University of Dodoma. P. O. Box 259, Dodoma, Tanzania
  • 3Department of Pharmacognosy, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, MS, 38677, USA

The genus Brackenridgea belongs to the family Ochnaceae and consists of approximately 12 species distributed from Africa to the Fiji Islands. Brackenridgea zanguebarica has been used as a traditional African medicine for the treatment of wounds, conjunctivitis and anemia. Various chalcone dimers have been reported from this family. These dimers are of interest due to the inconsistent isomers that result from chalcone framework. Herein, we report the isolation of two new dimeric (1 and 2) and one new tetrameric chalcones (3) along with four known compounds. Their structures were elucidated through spectroscopic methods, including NMR experiments and MS spectra analyses.

Acknowledgements: The research was supported by USDA Agricultural Research Service Specific Cooperative Agreement No. 58 – 6408 – 2-0009 and The United States Food and Drug Administration (FDA) grant entitled “Science Based Authentication of Dietary Supplements” Number 5U01FD00 4246.