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Bioactive Flavaglines and Other Constituents Isolated from Aglaia perviridis
Eight new compounds, including four flavaglines (1 – 4) and four triterpenoids (5 – 8), together with 16 known compounds, were isolated from Aglaia perviridis collected in Vietnam. The new compounds 2 – 4 and seven known rocaglate derivatives (9 – 15) exhibited significant cytotoxicity against the HT-29 cell line. The cytotoxic compounds were further evaluated against a normal colon cell line, CCD-112CoN. In addition, the new compound perviridicin B (2) and four known compounds (9, 11, 12 and 17), showed significant NF-κB (p65) inhibitory activity in an ELISA assay.