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Antiproliferative Withanolides from Datura wrightii
A new withanolide 1 named withawrightolide, and four known withanolides 2-5 were isolated from the aerial parts of Datura wrightii Regel (Solanaceae). The structure of compound 1 was elucidated through 2D NMR and other spectroscopic techniques. In addition, the structure of withametelin L 2 was confirmed by X-ray crystallographic analysis. Using MTS viability assays, withanolides 1-5 showed antiproliferative activities against human glioblastoma (U251 and U87), head and neck squamous cell carcinoma (MDA-1986), and normal fetal lung fibroblast (MRC-5) cells with IC50 values in the range between 0.56 and 5.6 µM.