Planta Med 2013; 79 - PN22
DOI: 10.1055/s-0033-1348703

Antiparasitic and Antimicrobial Constituents from Terminalia brownii

F Machumi 1, J Zhang 1, JO Midiwo 2, MR Jacob 1, SI Khan 1, 3, BL Tekwani 1, 4, LA Walker 1, 4, I Muhammad 1
  • 1National Center for Natural Products Research
  • 3Department of Pharmacognosy
  • 4Department of Pharmacology, School of Pharmacy, University of Mississippi, University, MS 38677, USA
  • 2Department of Chemistry, University of Nairobi, P.O. Box 30197 – 00100, Nairobi, Kenya

Terminalia brownii is an African medicinal plant used to treat parasitic and microbial infections. A new oleanane-type triterenoid was isolated from its stem bark extract by bioassay-guided fractionation using the method of chromatographic separations and was identified as 3,24-O-ethylidenyl-2,19-dihydroxyolean-12-en-28-oic acid (1), along with seven known oleanane-type triterpenoids and seven ellagic acid derivatives. The compounds were evaluated for their antiplasmodial, antileishmanial and antimicrobial activities giving the most potent antiplasmodial activity with IC50 values of 2.76 µg/mL for 23-galloylarjunolic acid (2) against P. falciparum W2 strain and the most potent antimicrobial activity with IC50 values of 0.32 µg/mL for diellagic lactone (3) against C. glabrata.