Antiparasitic and Antimicrobial Constituents from Terminalia brownii

F Machumi; J Zhang; JO Midiwo; MR Jacob; SI Khan; BL Tekwani; LA Walker; I Muhammad

doi:10.1055/s-0033-1348703

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Planta Med 2013; 79 - PN22
DOI: 10.1055/s-0033-1348703

Antiparasitic and Antimicrobial Constituents from Terminalia brownii

F Machumi ¹, J Zhang ¹, JO Midiwo ², MR Jacob ¹, SI Khan ¹^,³, BL Tekwani ¹^,⁴, LA Walker ¹^,⁴, I Muhammad ¹

¹National Center for Natural Products Research
³Department of Pharmacognosy
⁴Department of Pharmacology, School of Pharmacy, University of Mississippi, University, MS 38677, USA
²Department of Chemistry, University of Nairobi, P.O. Box 30197 – 00100, Nairobi, Kenya

Congress Abstract

Terminalia brownii is an African medicinal plant used to treat parasitic and microbial infections. A new oleanane-type triterenoid was isolated from its stem bark extract by bioassay-guided fractionation using the method of chromatographic separations and was identified as 3,24-O-ethylidenyl-2,19-dihydroxyolean-12-en-28-oic acid (1), along with seven known oleanane-type triterpenoids and seven ellagic acid derivatives. The compounds were evaluated for their antiplasmodial, antileishmanial and antimicrobial activities giving the most potent antiplasmodial activity with IC₅₀ values of 2.76 µg/mL for 23-galloylarjunolic acid (2) against P. falciparum W2 strain and the most potent antimicrobial activity with IC₅₀ values of 0.32 µg/mL for diellagic lactone (3) against C. glabrata.