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Planta Med 2013; 79 - PN17
DOI: 10.1055/s-0033-1348698
DOI: 10.1055/s-0033-1348698
Antileukemic Anthraquinones from Asphodelus microcarpus
Bioassay guided fractionation of the ethanolic extract of Asphodelus microcarpus Salzm.et Vivi (Asphodelaceae) led to the isolation and characterization of antileukemic anthraquinones, asphodelin-10'-oxanthrone-10'-β-D-arabinopyranoside (1), asphodelin-10'-oxanthrone-10'-β-D-xylopyranoside (2), chrysalodin-10'-oxanthrone-10'-β-D-glucopyranoside (3) and also, known anthraquinones; ramosin (4) and emodin (5), in which 1, 2 and 3 are new and results are summarized in table 1.
Compound |
Estimated IC50 (µM) |
Compound |
Estimated IC50 (µM) |
||
HL60 cells |
K562 cells |
HL60 cells |
K562 cells |
||
1 |
0.07 |
0.29 |
4 |
1.50 |
2.50 |
2 |
0.35 |
0.36 |
5 |
1.50 |
2.90 |
3 |
3.10 |
4.10 |