Planta Med 2013; 79 - PN11
DOI: 10.1055/s-0033-1348692

Antibacterial Compounds from Atalantia monophylla Roots and Stems

T Sripisut 1, S Deachathai 1, LC Chang 2, S Laphookhieo 1
  • 1Natural Products Research Laboratory, School of Science, Mae Fah Luang University, Chiang Rai 57100, Thailand
  • 2Department of Pharmaceutical Sciences, College of Pharmacy, University of Hawaii at Hilo, Hilo, HI, 96720, United States

A phytochemical investigation of the roots and stems of Atalantia monophylla led to the isolation and identification of sixteen known compounds including nine acridone alkaloids (1 – 9), six coumarins (10 – 15) and a limonoid (16). Their structures were elucidated through a series of 1D and 2D NMR experiments. Some isolated compounds were further evaluated for their antibacterial activity against Gram-positive and Gram-negative bacteria. Only compound 2 exhibited strong activity against Methicillin-resistant Staphyloccocus aureus SK1 and S. aureus with MIC values of 2 and 4 µg/mL, respectively.