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Analgesic and Anti-Inflammatory Activities of the Ethanolic Extract of Artemisia Morrisonesis Hayata in Mice
The aim of this study was to investigate the analgesic/anti-inflammatory mechanisms of the ethanolic extract of A. morrisonensis Hayata (AMEtOH). AMEtOH decreased writhing response for acetic acid assay and the licking time in the formalin test. The results indicated that the anti-inflammatory mechanism of AMEtOH may be due to the declined levels of NO and MDA in the edematous paw. AMEtOH decreased the TNF-α and IL-6 levels, leading to the reduction of prostaglandins and subsequently alleviated edema. Isolation and purification of the AMEtOH extract determined p-hydroxyacetophenone to be a major component at 130 mg/g of extract. This study demonstrated the possible mechanisms for analgesic/anti-inflammatory effects of AMEtOH for mice.