Planta Med 2013; 79 - PL37
DOI: 10.1055/s-0033-1348678

Tripartin, a Histone Demethylase Inhibitor from a Bacterium Associated with a Dung Beetle Larva

SH Kim 1, SH Kwon 2, SH Park 1, JK Lee 3, HS Bang 4, SJ Nam 5, HC Kwon 6, J Shin 1 DC Oh 1*
  • 1College of Pharmacy, Seoul National University, Seoul, Republic of Korea
  • 2College of Pharmacy, Yonsei University, Incheon, Republic of Korea
  • 3Neuro-Medicine Center, Korea Institute of Science and Technology, Seoul, Republic of Korea
  • 4Department of Agricultural Environment, National Academy of Agricultural Science, Suwon, Republic of Korea
  • 5Department of Chemistry and Nano Science, Ewha Womans University, Seoul, Republic of Korea
  • 6Natural Products Research Center, Korea Institute of Science and Technology, Gangneung, Gangwon-do, Republic of Korea

Tripartin (1), a new dichlorinated indanone, was isolated from the culture broth of the Streptomyces sp. associated with a larva of the dung beetle Copris tripartitus Waterhouse. The planar structure of tripartin (1) was identified by the spectroscopic analyses of NMR, mass, UV, and IR data. The structure was confirmed, and the absolute configuration of 1 was determined by X-ray crystallography. Tripartin displayed specific activity as an inhibitor of the histone H3 lysine 9 demethylase KDM 4 in HeLa cells.