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Planta Med 2013; 79 - PL37
DOI: 10.1055/s-0033-1348678
DOI: 10.1055/s-0033-1348678
Tripartin, a Histone Demethylase Inhibitor from a Bacterium Associated with a Dung Beetle Larva
Tripartin (1), a new dichlorinated indanone, was isolated from the culture broth of the Streptomyces sp. associated with a larva of the dung beetle Copris tripartitus Waterhouse. The planar structure of tripartin (1) was identified by the spectroscopic analyses of NMR, mass, UV, and IR data. The structure was confirmed, and the absolute configuration of 1 was determined by X-ray crystallography. Tripartin displayed specific activity as an inhibitor of the histone H3 lysine 9 demethylase KDM 4 in HeLa cells.