The Discovery of Angelica Dahurica Roots Extracts Exhibiting Anti-Quorum Sensing Properties

Quorum sensing (QS) or bacterial cell-to-cell communication refers to signalling network which allows the bacteria to do a quick survey of their surrounding and coordinates different behaviours as the population has reached a high cell density. Previous research has shown that higher plants can produce compounds that can attenuate the bacterial pathogenicity by mimicking the chemical structures of the bacterial QS signalling molecules and thus, will jam their command language. Our group has previously showed that malabaricone C extracted from the Malaysian Myristica cinnamomea attenuate the QS-mediated virulence determinants in the pathogenic bacteria. This research aimed to study the effects of Angelica dahurica roots extracts against QS. By using the bioassay guided isolation, the sample was found to inhibit the violacein production in Chromobacterium violaceum CV026 as well as inhibit the selected virulence determinants of Pseudomonas aeruginosa PA01. Our data validate the use of higher plants as rich source of anti-QS compounds that can attenuate the bacteria virulence which may be valuable source for novel drug discovery.