Subscribe to RSS
DOI: 10.1055/s-0033-1348668
New Secondary Metabolites from the Endophytic Fungus Alternaria phragmospora
In this study, phytochemical and biological investigation for the Endophytic Fungus Alternaria phragmospora was proceeded. The endophytic fungus Alternaria phragmospora was isolated from Vinca rosea (Apocynaceae) leaves growing in Egypt. In vitro antileukemic and antimalarial activities of the isolated secondary metabolites (1 – 4) were examined. The isolated compounds were chemically identified as 5-butyl-4-methoxy-6-methyl-2H-pyran-2-one (1), 5-butyl-6-(hydroxymethyl)-4-methoxy-2H-pyran-2-one (2), 6-(hydroxymethyl)-4-methoxy-5-(3-oxobutyl)-2H-pyran-2-one (3) and monocerin (4), Compounds 1, 2 and 3 are new compounds. Compounds 1 and 4 showed a promising antimalarial activity with IC50 values of 4.74 and 0.528 µg/mL, respectively