Planta Med 2013; 79 - PL27
DOI: 10.1055/s-0033-1348668

New Secondary Metabolites from the Endophytic Fungus Alternaria phragmospora

AM Metwaly 1, 4, HA Kadry 4, AA El-Hela 4, AEI Mohammad 4, SJ Cutler 3 SA Ross 1, 2*
  • 1National Center for Natural Products Research
  • 2Department of Pharmacognosy
  • 3Department of Medicinal Chemistry, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
  • 4Departments of Pharmacognosy, Faculty of Pharmacy, University of Al-Azhar, Cairo, Egypt

In this study, phytochemical and biological investigation for the Endophytic Fungus Alternaria phragmospora was proceeded. The endophytic fungus Alternaria phragmospora was isolated from Vinca rosea (Apocynaceae) leaves growing in Egypt. In vitro antileukemic and antimalarial activities of the isolated secondary metabolites (1 – 4) were examined. The isolated compounds were chemically identified as 5-butyl-4-methoxy-6-methyl-2H-pyran-2-one (1), 5-butyl-6-(hydroxymethyl)-4-methoxy-2H-pyran-2-one (2), 6-(hydroxymethyl)-4-methoxy-5-(3-oxobutyl)-2H-pyran-2-one (3) and monocerin (4), Compounds 1, 2 and 3 are new compounds. Compounds 1 and 4 showed a promising antimalarial activity with IC50 values of 4.74 and 0.528 µg/mL, respectively