Planta Med 2013; 79 - PL6
DOI: 10.1055/s-0033-1348647

Bioactive S-containing Sulochrin Dimers and other Metabolites from a Fungal Isolate Derived from the Soil Sample of Wailua Fall in Hawaii

S Cai 1, 2, JB King 1, 2, L Du 1, 2, DR Powell 2 RH Cichewicz 1, 2*
  • 1Natural Products Discovery Group, Institute for Natural Products Applications and Research Technologies, Stephenson Life Sciences Research Center, 101 Stephenson Parkway, University of Oklahoma, Norman, OK, 73019
  • 2Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, 101 Stephenson Parkway, University of Oklahoma, Norman, OK, 73019

Two new bioactive S-containing sulochrin dimers, polluxochrin (1) and dioschrin (2), were purified from the fungal isolate, Wailua PDA-3. Both of them displayed antibacterial activity and 1 showed potent antitumor activity (100 nM). Interestingly, 1 was unstable in water, it could transform to 2 and then castochrin (3), which lost all the activities at all. Another 19 metabolites (10 new structures), including sulochrins, anthraquinones, pyrenochaetic acids, asterric acids, and dimeric members of the secalonic acid family, were also isolated from this fungus.