Secondary Metabolites from the Soft Coral Sinularia nanolobata

CY Duh; FY Hsu; SK Wang

doi:10.1055/s-0033-1348637

Planta Medica, Table of Contents

Secondary Metabolites from the Soft Coral Sinularia nanolobata

CY Duh ¹, FY Hsu ¹, SK Wang ²

¹Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
²Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan

Abstract

Soft coral Sinularia nanolobata was reported to contain xeniaphyllane-type diterpenoids, caryophyllane-type norsesquiterpenoids, and furanone derivative. An investigation on the chemical constituents of the coral Sinularia nanolobata collected at San-Shen-Tai has led to the isolation of six new compounds (1-6), including two novel skeletons (1 and 2), two new diterpenoids (3 and 4), and two new norsesquiterpenes (5 and 6). The structures of these compounds were determined on the basis of their spectroscopic analysis (¹H NMR, ¹³C NMR, ¹H-¹H COSY, HSQC, HMBC, IR and HRESIMS) and their cytotoxic and antiviral activities were evaluated.