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Planta Med 2013; 79 - PE9
DOI: 10.1055/s-0033-1348577
DOI: 10.1055/s-0033-1348577
Insights on Possible Mechanism of Action of Vasorelaxant Activity Exhibited by Fungal Malbrancheamides
The alkaloids 1 – 3 biosynthesized by the coprophilous fungus Malbranchea aurantiaca displayed a significant vasorelaxant effect on endothelium-intact rat aortic rings pre-contracted with norepinephrine. This effect was not reduced when indomethacin, atropine or tetraethylamonium were added to the organ bath. Nevertheless, it was reduced in the presence of L-NAME, an inhibitor of the enzyme Nitric Oxide Synthase (NOS), suggesting that the pharmacological action was mediated by a nitrergic mechanism, as predicted by docking studies, were 1 showed a strong affinity by NOS.
Malbrancheamide (1) |
R1= Cl R2= Cl |
Malbrancheamide B (2) |
R1= Cl R2= H |
Isomalbrancheamide B (3) |
R1= H R2= Cl |