Subscribe to RSS
Heteroaromatic Analogs of Curcumin: Design, Synthesis, and Cytotoxic Activities
Abstract: N-containing heteroaromatic analogs of curcumin have been designed as compounds with improved bioavailability and the potential to treat advanced hormone-refractory prostate cancer. This design is based on the fundamental hypothesis that replacement of two substituted phenyls in curcumin with two identical N-containing heteroaromatics will produce compounds with improved bioavailability and potential anticancer activity. Three classes (I-III) of heteroaromatic curcumin analogs (more than 10 new compounds) have been synthesized employing a double aldol condensation reaction. The cytotoxicity of the synthesized curcumin analogs has been determined against both human androgen-independent and androgen-dependent prostate cancer cell lines (PC-3 and DU-145). The synthesis of heteroaromatic analogs together with their cytotoxic activities will be presented.