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DOI: 10.1055/s-0033-1348534
Gastroprotective Effect of Hintonia latiflora and Hintonia standleyana Aqueous Extracts and Compounds
The stem barks of Hintonia latiflora (HL) and H. standleyana (HS) locally known as “copalchi” are used for treating several maladies such as diabetes and gastrointestinal complaints, including gastric ulcers. Investigation of the acute toxicity revealed that infusions of the leaves (HLL and HSL) and stem barks (HLSB and HSSB) of both Hintonia species were not toxic to mice (LD50 > 5000 mg/kg in all cases). HLSB, HSSB, HLL and HSL provoked a significant gastroprotective effect [80.5 ± 3.35% (ED50= 184.7 mg/kg), 80.26 ± 3.96%, 75.1 ± 7.26% (ED50= 109.1 mg/kg), 76.85 ± 3.17% (ED50= 149.7 mg/kg) of gastroprotection respectively]. Compounds 1 and 2, present in all the extracts, were also active [68.85 ± 8.4% (ED50= 15 mg/kg), 74.04 ± 4.4% (ED50= 26 mg/kg) of gastroprotection respectively] and their mode of action involved non-protein sulfhydryl endogenous compounds.