Planta Med 2013; 79 - CL9
DOI: 10.1055/s-0033-1348534

Gastroprotective Effect of Hintonia latiflora and Hintonia standleyana Aqueous Extracts and Compounds

S Cristians 1, R Bye 2, A Navarrete 1, R Mata 1
  • 1Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Mexico City, 04510, Mexico
  • 2Instituto de Biología, Universidad Nacional Autónoma de México, Mexico City, 04510, Mexico

The stem barks of Hintonia latiflora (HL) and H. standleyana (HS) locally known as “copalchi” are used for treating several maladies such as diabetes and gastrointestinal complaints, including gastric ulcers. Investigation of the acute toxicity revealed that infusions of the leaves (HLL and HSL) and stem barks (HLSB and HSSB) of both Hintonia species were not toxic to mice (LD50 > 5000 mg/kg in all cases). HLSB, HSSB, HLL and HSL provoked a significant gastroprotective effect [80.5 ± 3.35% (ED50= 184.7 mg/kg), 80.26 ± 3.96%, 75.1 ± 7.26% (ED50= 109.1 mg/kg), 76.85 ± 3.17% (ED50= 149.7 mg/kg) of gastroprotection respectively]. Compounds 1 and 2, present in all the extracts, were also active [68.85 ± 8.4% (ED50= 15 mg/kg), 74.04 ± 4.4% (ED50= 26 mg/kg) of gastroprotection respectively] and their mode of action involved non-protein sulfhydryl endogenous compounds.