Planta Med 2013; 79 - IL9
DOI: 10.1055/s-0033-1348488

Unlocking Cryptic Fungal Natural Product Clusters

N Keller 1
  • 1Department of Medical Microbiology and Immunology, University of Wisconsin, Madison

Secondary metabolites (SMs) play central roles as fitness factors of fungi; however, genomic analyses suggest that the majority of fungal SMs have remained uncharacterized. Our lab has designed several methodologies to identify SMs ranging from mutagenesis schemes to novel microfluidic cultural manipulations. This presentation will highlight these methodologies through recent advances from our lab including identification of two non-ribosomal peptide synthetase (NRPS) gene clusters in human and plant pathogenic Aspergilli.