Relation between [18F]-FDG-PET/CT and volume perfusion-CT in primary tumors and mediastinal lymph nodes of non-small cell lung cancer

Ziele: The aim of this study was to investigate relations between glucose metabolism as registered by 2-deoxy-2-[18F]fluoro-D-glucose-PET/CT ([18F]FDG-PET/CT) and tumor perfusion as quantified by volume perfusion-CT (VPCT) in primary tumors and mediastinal lymph nodes of patients with non-small cell lung cancer. Methode: 17 patients with non-small cell lung cancer and 56 lymph nodes were enrolled. SUVmax and SUVavg were used for quantification of [18F]FDG uptake. Blood flow (BF), blood volume (BV) and flow extraction product (Ktrans) were determined as perfusion parameters. Perfusion parameters and [18F]FDG uptake values were subsequently correlated with each other. Ergebnis: No correlations were found between perfusion parameters and [18F]FDG uptake, for the primary tumors. Negative correlations were calculated between BF and SUVavg (r =- 0.383), BV and SUVavg (r =- 0.406), BV and SUVmax (r =- 0.377), but not between BF and SUVmax, Ktrans and SUVavg, Ktrans and SUVmax, respectively. In addition, negative correlations existed in the >2.5 SUVmax group between BF and SUVavg (r =- 0.510), BV and SUVavg (r =- 0.390), BF and SUVmax (r =- 0.536), BV and SUVmax (r =- 0.346), respectively. Schlussfolgerung: Glucose metabolism and perfusion seem to be negatively correlated in mediastinal lymph nodes, but uncoupled in large primary tumors. These results may help to advance tumor staging and therapy monitoring.

Korrespondierender Autor: Sauter W

Radiologische Klinik, Abteilung für Diagnostische und Interventionelle Radiologie, Hoppe-Seyler-Str. 3, 72076 Tübingen

E-Mail: [e-mail]

NSCLC - perfusion - PET/CT - FDG