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Synthesis 2014; 46(14): 1954-1956
DOI: 10.1055/s-0033-1341158
DOI: 10.1055/s-0033-1341158
paper
Facile Synthesis of the Isoquinoline Alkaloids Doryanine and Oxyhydrastinine
Further Information
Publication History
Received: 06 February 2014
Accepted after revision: 20 March 2014
Publication Date:
10 April 2014 (online)
Abstract
Starting from 4,5-(methylenedioxy)homophthalic acid, a concise and efficient synthesis of the isoquinoline alkaloids doryanine and oxyhydrastinine is described via the corresponding homophthalimide utilizing a one-pot regioselective reductive dehydration and catalytic hydrogenation pathway.
Key words
homophthalic acid - homophthalimide - regioselective reduction - dehydration - isoquinoline alkaloidsSupporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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