Synlett 2014; 25(3): 455-456
DOI: 10.1055/s-0033-1340480
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© Georg Thieme Verlag Stuttgart · New York

2-Halobenzamides

Shah Jaimin Balkrishna
Department of Chemistry, Indian Institute of Science Education and Research (IISER) Bhopal, Bhopal 462 023, MP, India   eMail: jaimin@iiserb.ac.in
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Publikationsverlauf

Publikationsdatum:
16. Dezember 2013 (online)

Introduction

2-Halobenzamides are important precursors in organic synthesis to construct various heterocyclic compounds. They exhibit strong intermolecular N–H···O=C hydrogen bonding[1a] and therefore, most of them are crystalline solids in nature and can be stored for a long period of time. Most of the 2-halobenzamides are soluble in organic solvents, for example, in dichloromethane, chloroform, acetone, methanol, etc.

 
  • References

    • 1a Zhu Y.-Y, Yi H.-P, Li C, Jiang X.-K, Li Z.-T. Cryst. Growth Des. 2008; 8: 1294
    • 1b Goswami S, Adak AK, Mukherjee R, Jana S, Dey S, Gallagher JF. Tetrahedron 2005; 61: 4289
    • 1c Kundu NG, Khan MW. Tetrahedron 2000; 56: 4777
    • 1d Furuta T, Kitamura Y, Hashimoto A, Fujii S, Tanaka K, Kan T. Org. Lett. 2007; 9: 183
    • 1e Thansandote P, Hulcoop DG, Langer M, Lautens M. J. Org. Chem. 2009; 74: 1673
  • 2 Liu C.-C, Parthasarathy K, Cheng C.-H. Org. Lett. 2010; 12: 3518
  • 3 Kavala V, Wang C.-C, Barange DK, Kuo C.-W, Lei P.-M, Yao C.-F. J. Org. Chem. 2012; 77: 5022
    • 4a Balkrishna SJ, Bhakuni BS, Chopra D, Kumar S. Org. Lett. 2010; 12: 5394
    • 4b Balkrishna SJ, Bhakuni BS, Kumar S. Tetrahedron 2011; 67: 9565
    • 4c Bhakuni BS, Balkrishna SJ, Kumar A, Kumar S. Tetrahedron Lett. 2012; 53: 1354
  • 5 Balkrishna SJ, Kumar S. Synthesis 2012; 44: 1417
  • 6 Bhakuni BS, Kumar A, Balkrishna SJ, Sheikh JA, Konar S, Kumar S. Org. Lett. 2012; 14: 2838
  • 7 Lu C, Dubrovskiy AV, Larock R. J. Org. Chem. 2012; 77: 8648
  • 8 Li L, Wang M, Zhang X, Jiang Y, Ma D. Org. Lett. 2009; 11: 1309
  • 9 Kitching MO, Hurst TE, Snieckus V. Angew. Chem. Int. Ed. 2012; 51: 2925