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Synthesis 2014; 46(18): 2451-2462
DOI: 10.1055/s-0033-1339139
DOI: 10.1055/s-0033-1339139
paper
Oxazole/Thiazole and Triazole Hybrids Based on α-Amino Acids
Weitere Informationen
Publikationsverlauf
Received: 30. Januar 2014
Accepted after revision: 29. April 2014
Publikationsdatum:
04. Juni 2014 (online)
Abstract
The Cu(I)-catalyzed Huisgen [3+2] cycloaddition is the basis of click chemistry to synthesize triazole derivatives by coupling azides with ethynyl blocks. In the development of new compounds inspired by bioactive natural products, the synthesis of new oxazole building blocks containing azide moiety and coupling them with aromatic alkynes via triazole linker is described. These oxazole building blocks are synthesized using amino acids as chiral and inexpensive starting materials. Using this approach, 16 new triazole-oxazole hybrids were synthesized.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000084.
- Supporting Information
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