Antimicrobial Activity of the Seed Kernel and Leaf Extracts of Mangifera indica L. (Fam. Anacardiaceae) Against Escherichia coli
Mango [Mangifera indica L. (Fam. Anacardiaceae)], particularly the carabao mango, is widely endemic in the Philippines and its seed kernels and mature leaves have many purported folkloric uses and pharmacologic activities that function as antioxidant, antitussive, antiviral, among others which were linked to its primary constituent, mangiferin, a xanthone glycoside. However, there are a limited number of studies on the antimicrobial activity of the aforementioned variety of mango. Hence, this study was carried out to qualitatively determine their chemical constituents and their possible antimicrobial activity. The general procedure performed was of two distinct sets: the (i) characterization of the crude extract, and (ii) the bioassay-guided fractionation. Results showed that the hexane fraction of the seed kernel possessed antimicrobial activity which was inferred to be due to the aglycone unit of mangiferin. It is recommended that spectroscopic tests (i.e. UV, IR, NMR, etc.) be conducted for further isolation and characterization. References:  He Q, Masibo M (2008) Comp Rev in Food Sci and Food Safety, 7(4): 309 – 319.  Shah KA, Patel MB, et al. (2010) Pharmacognosy Rev, 4(7): 42 – 48.  Jiagang D (2009) Study on mango leaf and mangiferin, <http://220.127.116.11/yxy/lanmu/lanmu_11/tyhy2009-3.files/wjxz/Study on Mango Leaf and Mangiferin.pdf>.  Quisumbing E (1978) Medicinal Plants of the Philippines, Katha Publishing Co., Quezon City, Philippines, 538 – 541.