Planta Med 2013; 79 - P51
DOI: 10.1055/s-0033-1336493

New Secondary Metabolites from Geosmithia lavendula

L Malak 1, 2, D Bishay 2, A Abdel-Baky 2, A Moharram 3, SJ Cutler 4, SA Ross 1, 5
  • 1National Center for Natural Products Research
  • 4Medicinal Chemistry Department and
  • 5Pharmacognosy Department, School of Pharmacy, University of Mississippi, University, MS 38677, USA
  • 2Pharmacognosy Department and
  • 3Assiut University Mycological Center, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

Geosmithia lavendula Pitt (Ascomycota: Hypocreales) is a dry-spored, lilac colored filamentous fungus and considered as associates built by bark beetles. Three anthraquinones were previously isolated from this fungus [1,2]. In this study, G. lavendula was grown on two different media and provided the isolation of three new anthraquinones; 1-acetyl-2,4,6,8-tetrahydroxy-9,10-anthraquinone (1), 2-acetyl-1,4,5,7-tetrahydroxy-9,10 anthraquinone (2) and 1-acetyl-2,4,5,6,7-pentahydroxy-9,10-anthraquinone (3) and didodecyl thiodipropionate (4) which is new as a naturally occurring compound along with ten known compounds: 1-acetyl-2,4,5,7- tetrahydroxy-9,10-anthraquinone (5), 1-acetyl-2,4,5,7,8-pentahydroxy-9,10-anthraquinone (6), (22E)-ergosta-6,22-diene-3β,5α,8α-triol, p-hydroxybenzyl alcohol, oleic acid, D-mannitol, palmitic acid, stearic acid, cis-vaccenic acid, and 2-decenal. Compound (1) exhibited moderate activity against methicillin resistant Staphylococcus aureus with an IC50 value of 16.12 µg/mL.

R 1

R 2

R 3

R 4

1

H

OH

H

OH

3

OH

OH

OH

H

5

OH

H

OH

H

6

OH

H

OH

OH

Acknowledgements: Thanks to the Egyptian Government and National Center for Natural Products Research, University of Mississippi for their financial support and for Drs. M. Jacob, B. Tekwani, S. Khan for performing the bioassays and Dr. M. Wang for performing GC/MS analysis. References: [1] Stodulkova E, et al. (2010) J Chromatogr A, 1217: 6296 – 6302. [2] Stodulkova E, et al. (2009) Folia Microbiol, 54: 179 – 187.