Planta Med 2013; 79 - P7
DOI: 10.1055/s-0033-1336449

Anticandidal and Antioxidant Activities of Fractions and Isolated Compounds of Pyrostegia venusta (Ker Gawl.) Miers

AMS Pereira 1, C Hernandes 1, SIV Pereira 1, BW Bertoni 1, SC França 1, PS Pereira 1, SH Taleb-Contini 1
  • 1Departamento de Biotecnologia de Plantas Medicinais, Universidade de Ribeirão Preto, 14096 – 380, Ribeirão Preto, SP, Brazil

The in vitro anticandidal and antioxidant activities of phenolic compounds detected in flower extracts of Pyrostergia venusta were investigated. One flavonoid (quercetin-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-galactopyranoside) and two phenylpropanoid glycosides (verbascoside and isoverbascoside) were purified by using the HPLC technique. The antimicrobial activity of the extracts was evaluated against five Candida strains (C. albicans, C. krusei ATCC 6258, and clinical isolates strains of Candida sp: C. albicans, C. krusei, C. tropicalis, C. parapsilosis and C. guilhermondii). The antimicrobial and antioxidant activities were confirmed in extracts. Semi-purified fraction and verbascoside showed similar activity to amphotericin B. Acknowledgements: Ouro FinoAgribusiness