Myoepithelioma of the Skull Base and Orbit: Case Report, Immunohistopathology and Surgical Considerations

Myoepithelial neoplasms are rare tumors that originate most commonly from the parotid glands, salivary glands, and soft tissues of the limbs and limb girdles. Intracranial myoepitheliomas have been documented to arise from the sellar region, cerebellopontine angle, convexity of the skull, and lacrimal gland. To date, there has been no report of a primary myoepithelial neoplasm of the skull base. To the best of our knowledge, we are the first to report a primary myoepithelial tumor of the middle cranial fossa with extension into the orbit. In addition to the location, genetics, immunohistopathology, and radiographic findings of myoepithelial tumors, we review surgical workup and management strategy for these rare but increasingly more recognized intracranial neoplasms.