Adenomyosis and Subfertility: Evidence of Association and Causation

Carla Tomassetti; Christel Meuleman; Dirk Timmerman; Thomas D'Hooghe

doi:10.1055/s-0032-1333475

Seminars in Reproductive Medicine, Inhaltsverzeichnis

Semin Reprod Med 2013; 31(02): 101-108
DOI: 10.1055/s-0032-1333475

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Adenomyosis and Subfertility: Evidence of Association and Causation

Authors

Carla Tomassetti

¹Department Obstetrics and Gynecology/Leuven University Fertility Center
Christel Meuleman

¹Department Obstetrics and Gynecology/Leuven University Fertility Center
Dirk Timmerman

²Department Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium
Thomas D'Hooghe

¹Department Obstetrics and Gynecology/Leuven University Fertility Center

Abstract

Due to the confounding or unknown presence of endometriosis in both cases and controls, it is difficult to test the hypothesis that adenomyosis causes infertility. Based on the limited available evidence, there is evidence to support a causal association between adenomyosis and subfertility: Adenomyosis is associated with lifelong infertility in baboons, is associated with impaired reproductive outcome after assistive reproductive technique, and a dose–effect relationship between the degree of adenomyosis and the degree of abnormal uterotubal contractility has been demonstrated. More and better designed studies are needed to assess the impact of adenomyosis on infertility in women with the laparoscopic-proven presence or absence of endometriosis.

Keywords

adenomyosis - infertility - causality

Volltext

Referenzen

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