In Vitro–Derived Gametes from Stem Cells

Franklin D. West; Reza Shirazi; Pezhman Mardanpour; Servet Ozcan; Gokcen Dinc; Dewey H. Hodges; Hamid Reza Soleimanpour-Lichaei; Karim Nayernia

doi:10.1055/s-0032-1331795

Seminars in Reproductive Medicine, Inhaltsverzeichnis

Semin Reprod Med 2013; 31(01): 033-038
DOI: 10.1055/s-0032-1331795

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

In Vitro–Derived Gametes from Stem Cells

Autoren

Franklin D. West

¹University of Georgia, Regenerative Bioscience Center, Athens, Georgia
Reza Shirazi

²Department of Anatomical Sciences, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
Pezhman Mardanpour

⁴Georgia Institute of Technology, Guggenheim School of Aerospace Engineering, Atlanta, Georgia
Servet Ozcan

⁵Department of Biology, Faculty of Science

⁶Genome and Stem Cell Research and Application Centre
Gokcen Dinc

⁶Genome and Stem Cell Research and Application Centre

⁷Department of Microbiology, Faculty of Medicine, Erciyes University, Kayseri, Turkey
Dewey H. Hodges

⁴Georgia Institute of Technology, Guggenheim School of Aerospace Engineering, Atlanta, Georgia
Hamid Reza Soleimanpour-Lichaei

³National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
Karim Nayernia

⁶Genome and Stem Cell Research and Application Centre

⁸GENEOCELL, Advanced Molecular and Cellular Technologies, Montreal, Canada

Abstract

Sperm and eggs are essential cells for reproduction and fertility in mammals. Lack of sperm production is one of the leading causes of infertility, a major and growing problem in the developed world affecting 13 to 18% of reproductive-age couples. The birth of the first test tube baby by in vitro fertilization marked an advance in infertility treatment. Later on, several important new techniques called assisted reproductive technologies were developed to help couples who experience infertility. One limiting factor is the requirement of reproductive cells (gametes) for use in in vitro fertilization. For azoospermic men lacking sperm cells, producing gametes in vitro could be a new window to overcome infertility. In the past few years, several reports have been published on generating germ cells from stem cells, one of the epitomes of which was the report on functional in vitro–derived (IVD) germ cells. These mature haploid sperm cells from mouse embryonic stem cells were capable of egg fertilization and producing live offspring. In tandem with previous advancements in germ cell research, development of new technologies based on IVD gametes will change the future of infertility and provide a new basis for the establishment of novel therapeutic approaches to cure more complicated conditions of infertility. In addition, IVD gametogenesis provides an accessible system for studying the specification and differentiation of sperm cells and related processes such as meiosis, morphogenesis, and motility.

Keywords

infertility - stem cells - germ cells - IVD gametes

Volltext

Referenzen

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