Drug Res (Stuttg) 2013; 63(01): 34-37
DOI: 10.1055/s-0032-1331693
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Enantioselective Disposition after Single Dose I.V Administration of Ketorolac in Male Wistar Rats

S. K. Dubey
1   Department of Pharmacy, Birla Institute of Technology & Science, Pilani, India
,
R. N. Saha
1   Department of Pharmacy, Birla Institute of Technology & Science, Pilani, India
,
N. Mittapelly
1   Department of Pharmacy, Birla Institute of Technology & Science, Pilani, India
,
A. Anand
1   Department of Pharmacy, Birla Institute of Technology & Science, Pilani, India
› Institutsangaben
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Publikationsverlauf

received 30. September 2012

accepted 20. November 2012

Publikationsdatum:
08. Januar 2013 (online)

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Abstract

Ketorolac, a commonly used anti-inflamatory and analgesic agent, was studied in male wistar rats. The plasma samples were analysed using chiral AGP column with UV detection. The experimental data was analysed for probable fit in the compartmental and non-compartmental models using WinNolin software. The data of (+)-R-Ketorolac and (−)-S-Ketorolac was found to fit into the compartmental as well as non compartmental model. There was a difference between the plasma concentrations of (+)-R-Ketorolac and (−)-S-Ketorolac; the plasma concentrations of (+)-R-Ketorolac were higher than those of (−)-S-Ketorolac throughout the time course of the study. The area under the curve (AUC) of time vs. concentration profile of (+)-R-Ketorolac was found to be higher than (−)-S-Ketorolac. Volume of distribution and clearance was found to be higher for (−)-S-Ketorolac.