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Fortschr Neurol Psychiatr 2013; 81(04): 210-229
DOI: 10.1055/s-0032-1330526
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© Georg Thieme Verlag KG Stuttgart · New York

Wertigkeit der bioptischen Diagnostik in der Neurologie

Biopsy Diagnosis in Neurology
K. Koelble
,
A. Herring
,
K. Keyvani
Further Information

Publication History

Publication Date:
15 April 2013 (online)

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Lernziele

Ziel des Artikels ist es, folgende Kenntnisse zu vermitteln:

  • Kenntnisse zur Handhabung von Gewebsproben und zum Spektrum der neuropathologischen Methoden, deren Einsatz im Rahmen der bioptischen Abklärung neurologischer Krankheitsbilder von Bedeutung ist,

  • allg. Abschätzung der durch morphologische Diagnostik gegenüber alternativen Verfahren zu erwartenden diagnostischen Ausbeute,

  • neuropathologische Grundlagen der Indikationen für bioptische Maßnahmen,

  • ein auf molekulargenetischen Ursachen basierender globaler Überblick über die Hirnerkrankungen, Neuropathien und Myopathien, bei denen eine morphologische Abklärung wesentliche (differenzial-)diagnostische Beiträge liefern kann.

 

  • Literatur

  • 1 Tews DS, Goebel HH. Diagnostic immunohistochemistry in neuromuscular disorders. Histopathology 2005; 46: 1-23
    CrossrefPubMedGoogle Scholar
  • 2 Steiner I, Budka H, Chaudhuri A et al. Viral meningoencephalitis: a review of diagnostic methods and guidelines for management. Eur J Neurol 2010; 17: 999-1009
    CrossrefPubMedGoogle Scholar
  • 3 Popescu BF, Lucchinetti CF. Pathology of demyelinating diseases. Annu Rev Pathol 2012; 7: 185-217
    CrossrefPubMedGoogle Scholar
  • 4 Birnbaum J, Hellmann DB. Primary angiitis of the central nervous system. Arch Neurol 2009; 66: 704-709
    CrossrefPubMedGoogle Scholar
  • 5 Kastrup O, van de Nes J, Gasser T et al. Three cases of CLIPPERS: a serial clinical, laboratory and MRI follow-up study. J Neurol 2011; 258: 2140-2146
    CrossrefPubMedGoogle Scholar
  • 6 Schott JM, Reiniger L, Thom M et al. Brain biopsy in dementia: clinical indications and diagnostic approach. Acta Neuropathol 2010; 120: 327-341
    CrossrefPubMedGoogle Scholar
  • 7 Leitlinie der Deutschen Gesellschaft für Neurologie 2008. Diagnostik bei Polyneuropathien. Online im Internet: http://www.dgn.org/images/stories/dgn/leitlinien/LL2008 / ll08kap_048.pdf 28.11.2012
    PubMedGoogle Scholar
  • 8 Sommer C, Brandner S, Dyck PJ et al. 147th ENMC international workshop: guideline on processing and evaluation of sural nerve biopsies, 15–17 December 2006, Naarden, The Netherlands. Neuromuscul Disord 2008; 18: 90-96
    CrossrefPubMedGoogle Scholar
  • 9 Hall SM, Hughes RA, Atkinson PF et al. Motor nerve biopsy in severe Guillain-Barré syndrome. Ann Neurol 1992; 31: 441-444
    CrossrefPubMedGoogle Scholar
  • 10 Willison HJ, Yuki N. Peripheral neuropathies and anti-glycolipid antibodies. Brain 2002; 125: 2591-2625
    CrossrefPubMedGoogle Scholar
  • 11 Koski CL, Baumgarten M, Magder LS et al. Derivation and validation of diagnostic criteria for chronic inflammatory demyelinating polyneuropathy. J Neurol Sciences 2009; 277: 1-8
    CrossrefPubMedGoogle Scholar
  • 12 Nilsen R, Mengistu G, Reddy BB. The role of nerve biopsies in the diagnosis and management of leprosy. Leprosy Rev 1989; 60: 28-32
    PubMedGoogle Scholar
  • 13 Hahn H, Husstedt IW, Arendt G. HIV-assoziierte Neuropathien. Nervenarzt 2010; 81: 409-417
    CrossrefPubMedGoogle Scholar
  • 14 Said G. Indications and usefulness of nerve biopsy. Arch Neurol 2002; 59: 1532-1535
    CrossrefPubMedGoogle Scholar
  • 15 Planté-Bordeneuve V, Said G. Familial amyloid polyneuropathy. Lancet Neurol 2011; 10: 1066-1097
    PubMedGoogle Scholar
  • 16 Oh SJ. Paraneoplastic vasculitis of the peripheral nervous system. Neurologic Clinics 1997; 15: 849-863
    CrossrefPubMedGoogle Scholar
  • 17 Hadden RDM, Nobile-Orazio E, Sommer C et al. European Federation of Neurological Societies/Peripheral Nerve Society Guideline on management of paraproteinemic demyelinating neuropathies. J Peripheral Nervous System 2006; 11: 9-19
    PubMedGoogle Scholar
  • 18 Lewis RA, Sumner AJ, Shy ME. Electrophysiological features of inherited demyelinating neuropathies: a reappraisal in the era of molecular diagnosis. Muscle Nerve 2000; 23: 1472-1487
    CrossrefPubMedGoogle Scholar
  • 19 Leitlinie der Deutschen Gesellschaft für Neurologie 2008. Diagnostik von Myopathien. Online im Internet: http://www.dgn.org/images/stories/dgn/leitlinien/LL2008 / ll08kap_066.pdf , 28.11.1012
    PubMedGoogle Scholar
  • 20 Schweitzer ME, Fort J. Cost-effectiveness of MR imaging in evaluating polymyositis. Am J Roentgenol 1995; 165: 1469-1471
    CrossrefPubMedGoogle Scholar
  • 21 Gallardo E, Rojas-García R, De Luna N et al. Inflammation in dysferlin myopathy: immunohistochemical characterization of 13 patients. Neurology 2001; 57: 2136-2138
    CrossrefPubMedGoogle Scholar
  • 22 Mammen AL. Autoimmune myopathies: autoantibodies, phenotypes and pathogenesis. Nat Rev Neurol 2011; 7: 343-354
    CrossrefPubMedGoogle Scholar
  • 23 Christopher-Stine L, Casciola-Rosen LA, Honget G et al. A novel autoantibody recognizing 200-kd and 100-kd proteins is associated with an immune-mediated necrotizing myopathy. Arthritis Rheum 2010; 62: 2757-2766
    CrossrefPubMedGoogle Scholar
  • 24 Dalakas MC. Sporadic inclusion body myositis – diagnosis, pathogenesis and therapeutic strategies. Nat Clin Pract Neurol 2006; 2: 437-447
    CrossrefPubMedGoogle Scholar
  • 25 Weihl CC, Pestronk A. Sporadic inclusion body myositis: possible pathogenesis inferred from biomarkers. Curr Opin Neurol 2010; 23: 482-488
    CrossrefPubMedGoogle Scholar
  • 26 Salajegheh M, Pinkus JL, Taylor JP et al. Sarcoplasmic redistribution of nuclear TDP-43 in inclusion body myositis. Muscle Nerve 2009; 40: 19-31
    CrossrefPubMedGoogle Scholar
  • 27 Mozaffar T, Lopate G, Pestronk A. Clinical correlates of granuloma in muscle. J Neurol 1998; 245: 519-524
    CrossrefPubMedGoogle Scholar
  • 28 O’Ferrall EK, Sinnreich M. The role of muscle biopsy in the age of genetic testing. Curr Opin Neurol 2009; 22: 543-553
    CrossrefPubMedGoogle Scholar
  • 29 Online Mendelian Inheritance in Man, OMIM. Baltimore, MD: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University; 03.08.2012 Online im Internet: DOI: http://omim.org/
    PubMedGoogle Scholar
  • 30 Thompson PD, Clarkson P, Karas RH. Statin-associated myopathy. JAMA 2003; 293: 1681-1690
    PubMedGoogle Scholar