Abstract
Objective To determine the risk factors for and the clinical course of postoperative meningitis
following lateral skull base surgery and to determine its relationship to cerebrospinal
fluid (CSF) fistula.
Patients Patients undergoing lateral skull base surgery between July 1999 and February 2010
at an academic tertiary referral center. All subjects had culture-proven meningitis
or suspected bacterial meningitis in the postoperative period. Medical records were
compared with the lateral skull base patients who did not develop meningitis.
Results Of 508 procedures, 16 patients developed meningitis (3.1%). The most common diagnosis
was acoustic neuroma in 81.3%; 68.8% of patients had a CSF leak prior to onset of
meningitis, and 50% received a lumbar drain. The median time from surgery to the onset
of meningitis was 12 days with a range of 2 to 880 days. The relative risk of developing
meningitis in the setting of postoperative CSF fistula is 10.2 (p <0.0001). No meningitis-associated mortality was observed.
Conclusions Postoperative meningitis occurred in a small number of patients undergoing lateral
skull base surgery. A postoperative CSF fistula leads to an increased risk of meningitis
by a factor of 10.2.
Keywords
meningitis - postoperative meningitis - acoustic neuroma
