Cocaine-Levamisole Thrombotic Vasculopathy

Irene A. Dy; Peter H. Wiernik

doi:10.1055/s-0032-1328889

Seminars in Thrombosis and Hemostasis, Table of Contents

Semin Thromb Hemost 2012; 38(08): 780-782
DOI: 10.1055/s-0032-1328889

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Cocaine-Levamisole Thrombotic Vasculopathy

Irene A. Dy

¹Department of Hematology and Oncology, St. Luke's Roosevelt Hospital Center, New York, New York

²Continuum Cancer Centers of New York, New York, New York

,

Peter H. Wiernik

¹Department of Hematology and Oncology, St. Luke's Roosevelt Hospital Center, New York, New York

²Continuum Cancer Centers of New York, New York, New York

› Author Affiliations

Abstract

The syndrome of cocaine-levamisole thrombotic vasculopathy is a tetrad of cutaneous manifestations, arthralgia, leukopenia, and positive antineutrophil cytoplasmic antigen (ANCA). Cocaine is cut with levamisole to potentiate its euphoric effects. However, along with this are the adverse reactions of levamisole such as fatal agranulocytosis, flu-like symptoms, and cutaneous thrombotic vasculopathy. High index of suspicion is needed for its diagnosis. This article will review on its toxicities, especially its prothrombotic effects.

Keywords

levamisole - cocaine - agranulocytosis - vasculitis - ANCA

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References

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