Planta Medica, Inhaltsverzeichnis Planta Med 2013; 79(12): 1051-1055DOI: 10.1055/s-0032-1328747 Natural Product Chemistry Original Papers Georg Thieme Verlag KG Stuttgart · New YorkDibenzocyclooctane Lignans from the Stems of Schisandra wilsoniana Wen-Hui Ma Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, P. R. China , Yan Lu Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, P. R. China , Dao-Feng Chen Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, P. R. China › InstitutsangabenArtikel empfehlen Abstract Artikel einzeln kaufen Abstract Five new dibenzocyclooctane lignans, schisanwilsonins K–O (1–5), together with eighteen known lignans (6–23) were isolated from the stems of Schisandra wilsoniana. The structures of these new compounds were elucidated by spectroscopic methods, including 2D-NMR techniques. Several compounds were found to show anti-HIV and anti-HBV activity. Key words Key words Schisandra wilsoniana - Schisandraceae - schisanwilsonin - dibenzocyclooctane lignan Volltext Referenzen References 1 Yang GY, Xiao WL, Chang Y, Wang RR, Pu JX, Gao XM, Lei C, Lu Y, Zheng YT, Sun HD. Nortriterpenoids from Schisandra wilsoniana . Helv Chim Acta 2008; 91: 1871-1878 2 Yang GY, Li YK, Wang RR, Li XN, Xiao WL, Yang LM, Pu JX, Zheng YT, Sun HD. Dibenzocyclooctadiene lignans from Schisandra wilsoniana and their anti-HIV-1 activities. J Nat Prod 2010; 73: 915-919 3 Yang GY, Li YK, Wang RR, Xiao WL, Yang LM, Pu JX, Zheng YT, Sun HD. Dibenzocyclooctadiene lignans from the fruits of Schisandra wilsoniana and their anti-HIV-1 activities. J Asian Nat Prod Res 2010; 12: 470-476 4 Yang GY, Wang RR, Mu HX, Li YK, Xiao WL, Yang LM, Pu JX, Zheng YT, Sun HD. Neolignans from Schisandra wilsoniana and their anti-human immunodeficiency virus-1 activities. Chem Pharm Bull 2011; 59: 1344-1347 5 Zhang XJ, Yang GY, Wang RR, Pu JX, Sun HD, Xiao WL, Zheng YT. 7,8-Secolignans from Schisandra wilsoniana and their anti-HIV-1 activities. Chem Biodivers 2010; 7: 2692-2701 6 Ma WH, Huang H, Zhou P, Chen DF. Schisanwilsonenes A–C, anti-HBV carotane sesquiterpenoids from the fruits of Schisandra wilsoniana . J Nat Prod 2009; 72: 676-678 7 Ma WH, Lu Y, Huang H, Zhou P, Chen DF. Schisanwilsonins A–G and related anti-HBV lignans from the fruits of Schisandra wilsoniana . Bioorg Med Chem Lett 2009; 19: 4958-4962 8 Wang HJ, Chen YY. Studies of lignans from Schisandra rubriflora Rhed et Wils. Acta Chim Sin 1985; 20: 832-841 9 Ikeya Y, Taguchi H, Yosioka I, Kobayashi H. The structures of four new lignans, gomisin H and its derivatives, angeloyl-, tigloyl- and benzoyl-gomisin H. Chem Pharm Bull 1979; 27: 1576-1582 10 Chen M, Liao ZX, Chen DF. Four new dibenzocyclooctene lignans from Kadsura renchangiana . Helv Chim Acta 2004; 87: 1368-1376 11 Liu JS, Li L. Schisantherins L–O and acetylschisantherin L from Kadsura coccinea . Phytochemistry 1993; 32: 1293-1296 12 Ikeya Y, Taguchi H, Sasaki H, Nakajima K, Yosioka I. The constituents of Schizandra chinensis Baill VI 13C nuclear magnetic resonance spectroscopy of dibenzocyclooctadiene lignans. Chem Pharm Bull 1980; 28: 2414-2421 13 Ikeya Y, Miji E, Okada M, Mitsuhashi H, Chai JG. Benzoylgomisin Q and benzoylgomisin P, two new lignans from Schisandra sphenanthera REHD et WILS. Chem Pharm Bull 1990; 38: 1408-1411 14 Ikeya Y, Sugama K, Okada M, Mitsuhashi H. Two lignans from Schisandra sphenanthera . Phytochemistry 1991; 30: 975-980 15 Chen DF, Zhang SX, Chen K, Zhou BN, Wang P, Cosentino LM, Lee KH. Two new lignans, interiotherins A and B, as anti-HIV principles from Kadsura interior . J Nat Prod 1996; 59: 1066-1068 16 Ikeya Y, Taguchi H, Yosioka I, Kobayashi H. The constituents of Schizandra chinensis BAILL V The structures of four new lignans, gomisin N, gomisin O, epigomisin O and gomisin E, and transformation of gomisin N to deangeloylgomisin B. Chem Pharm Bull 1979; 27: 2695-2709 17 Ikeya Y, Taguchi H, Yosioka I. The constituents of Schizandra chinensis BAILL. XII. Isolation and structure of a new lignan, gomisin R, the absolute structure of wuweizisu C and isolation of schisantherin D. Chem Pharm Bull 1982; 30: 3207-3211 18 Ikeya Y, Taguchi H. The constituents of Schizandra chinensis Baill. The structures of two new lignans, pre-gomisin and gomisin J. Chem Pharm Bull 1978; 26: 682-684 19 Tan R, Li LN, Fang QC. Studies on the chemical constituents of Kadsura longipedunculata: isolation and structure elucidation of five new lignans. Planta Med 1984; 50: 414-416 20 Chen YG, Qin GW, Xie YY. Dibenzocyclooctadiene lignans from Schisandra propinqua . Chem J Chin Univ 2001; 22: 1518-1521 21 Li LN, Hung X, Tan R. Dibenzocyclooctadiene lignans from roots and stems of Kadsura coccinea . Planta Med 1985; 4: 297-299 22 Ikeya Y, Taguchi H, Mitsuhashi H, Takeda S, Kase Y, Aburada M. A lignan from Schizandra chinensis . Phytochemistry 1988; 27: 569-573 23 Ikeya Y, Ookawa N, Taguchi H, Yosioka I. The constituents of Schizandra chinensis BAILL. XI. The structures of three new lignans, angeloylgomisin O, and angeloyl- and benzoylisogomisin O. Chem Pharm Bull 1982; 30: 3202-3206 24 Chen M, Kilgore N, Lee KH, Chen DF. Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora . J Nat Prod 2006; 69: 1697-1701 25 Wu T, Huang H, Zhou P. The inhibitory effects of enduracidin on hepatitis B virus in vitro . Zhongguo Bing Du Xue 1998; 13: 46-50 Zusatzmaterial Zusatzmaterial Supporting Information