Triterpene Saponins from Clematis mandshurica and Their Antiproliferative Activity

Abstract

Six new triterpene saponins, clematomandshurica saponins F–K (1–6), together with a known compound (7), were isolated from the roots and rhizomes of Clematis mandshurica. Their structures were elucidated on the basis of spectroscopic evidence and hydrolysis. Compounds 5–7 exhibited antiproliferative effects against PC-3 human prostate cancer cells with GI₅₀ values of 1.29, 1.50, and 0.71 µM, respectively.

Key words

Clematis mandshurica - Ranunculaceae - triterpene saponins - antiproliferative activity - prostate cancer PC-3

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