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Planta Med 2013; 79(11): 987-994
DOI: 10.1055/s-0032-1328657
DOI: 10.1055/s-0032-1328657
Natural Product Chemistry
Original Papers
Triterpene Saponins from Clematis mandshurica and Their Antiproliferative Activity
Further Information
Publication History
received 08 November 2012
revised 20 April 2013
accepted 12 May 2013
Publication Date:
26 June 2013 (online)
Abstract
Six new triterpene saponins, clematomandshurica saponins F–K (1–6), together with a known compound (7), were isolated from the roots and rhizomes of Clematis mandshurica. Their structures were elucidated on the basis of spectroscopic evidence and hydrolysis. Compounds 5–7 exhibited antiproliferative effects against PC-3 human prostate cancer cells with GI50 values of 1.29, 1.50, and 0.71 µM, respectively.
Key words
Clematis mandshurica - Ranunculaceae - triterpene saponins - antiproliferative activity - prostate cancer PC-3-
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