Planta Med 2013; 79(07): 533-537
DOI: 10.1055/s-0032-1328261
Women's Health
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Importance of Wine-Treated Angelica Sinensis Radix in Si Wu Tang, a Traditional Herbal Formula for Treating Womenʼs Ailments

Janis Y. X. Zhan
1   Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong SAR, China
,
Ken Y. Z. Zheng
1   Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong SAR, China
,
Kevin Y. Zhu
1   Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong SAR, China
,
Wendy L. Zhang
1   Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong SAR, China
,
Cathy W. C. Bi
1   Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong SAR, China
,
J. P. Chen
1   Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong SAR, China
,
Crystal Y. Q. Du
1   Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong SAR, China
,
Tina T. X. Dong
1   Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong SAR, China
,
David T. W. Lau
1   Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong SAR, China
,
Karl W. K. Tsim
1   Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong SAR, China
› Author Affiliations
Further Information

Publication History

received 10 August 2012
revised 06 January 2013

accepted 22 January 2013

Publication Date:
01 March 2013 (online)

Abstract

Si Wu Tang (Four Agents Decoction), a traditional Chinese decoction composed of Angelica Sinensis Radix, Chuanxiong Rhizoma, Paeoniae Radix Alba, and Rehmanniae Radix Praeparata in a ratio of 1 : 1 : 1 : 1, has been used to treat womenʼs diseases for more than a thousand years. According to the original description of Si Wu Tang, Angelica Sinensis Radix should be treated with wine. However, the importance of this wine-treated Angelica Sinensis Radix in Si Wu Tangʼs function has not been identified. In this article, the chemical and biological properties of two decoctions processed in different ways (Si Wu Tang with crude Angelica Sinensis Radix and Si Wu Tang with wine-treated Angelica Sinensis Radix) were compared for examination. The herbal decoction Si Wu Tang prepared from wine-treated Angelica Sinensis Radix contained much different amounts of its active compounds. Compared with Si Wu Tang using crude Angelica Sinensis Radix, Si Wu Tang prepared from wine-treated Angelica Sinensis Radix had better biological responses. Therefore, these findings accentuate the functional importance of herbs treated with wine in the Chinese decoction.

Supporting Information

 
  • References

  • 1 Zhang EQ. The Chinese materia medica. Shanghai: Publishing House of Shanghai University of Traditional Chinese Medicine; 1988
  • 2 Zhao ZZ, Liang ZT, Chan K, Lu GH, Lee ELM, Chen HB, Li L. A unique issue in the standardization of Chinese materia medica: Processing. Planta Med 2010; 76: 1975-1986
  • 3 Liu CX, Xiao PG. An introduction to Chinese materia medica. Beijing: Peking Union Medical College and Beijing Medical University Press; 1993: 168
  • 4 Ye DJ, Yuan ST. Dictionary of Chinese medicinal herbs preparation. Shanghai: Shanghai Scientific and Technical Publishers; 2005: 257-259
  • 5 Zheng YZ, Choi RCY, Li J, Xie HQH, Cheung AWH, Duan R, Guo AJY, Zhu JTT, Chen VP, Bi CWC, Zhu Y, Lau DDW, Dong TTX, Lau BWC, Tsim KWK. Ligustilide suppresses the biological properties of Danggui Buxue Tang: a Chinese herbal decoction composed of Radix Astragali and Radix Angelica sinensis . Planta Med 2009; 76: 439-443
  • 6 Hsu HY, Ho YH, Lin CC. Protection of mouse bone marrow by Si-Wu-Tang against whole body irradiation. J Ethnopharmacol 1996; 52: 113-117
  • 7 Liang QD, Gao Y, Tan HL, Guo P, Li YF, Zhou Z, Tan W, Ma ZC, Ma BP, Wang SQ. Effects of four Si-Wu-Tangʼs constituents and their combination on irradiated mice. Biol Pharm Bull 2006; 29: 1378-1382
  • 8 Liu L, Ma H, Tang YP, Chen WX, Lu Y, Guo JM, Duan JA. Discovery of estrogen receptor α modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cells. Bioorg Med Chem Lett 2012; 22: 154-163
  • 9 Wei Y, Hu J, Li H, Liu JG. Preparative isolation and purification of senkyunolide-I, senkyunolide-H, and ferulic acid from Rhizoma Chuanxiong using counter-current chromatography. J Sep Sci 2011; 34: 3426-3432
  • 10 Wen ZN, Wang ZJ, Wang S, Ravula R, Yang L, Xu J, Wang C, Zuo Z, Chow MSS, Shi L, Huang Y. Discovery of molecular mechanisms of traditional Chinese medicinal formula Si-Wu-Tang using gene expression microarray and connectivity map. PLoS One 2011; 6: e18278
  • 11 Yeh LL, Liu JY, Lin KS, Liu YS, Chiou JM, Liang KY, Tsai TF, Wang LH, Chen CT, Huang CY. A randomised placebo-controlled trial of a traditional Chinese herbal formula in the treatment of primary dysmenorrhoea. PLoS One 2007; 2: e719
  • 12 Campo G, Marchesini J, Bristot L, Monti M, Gambetti S, Pavasini R, Pollina A, Ferrari R. The in vitro effects of verbascoside on human platelet aggregation. J Thromb Thrombolysis advance online publication 22 June 2012 DOI: 10.1007/s11239-012-0757-z.
  • 13 Chan S, Cheng T, Lin G. Relaxation effects of ligustilide and senkyunolide A, two main constituents of Ligusticum chuanxiong, in rat isolated aorta. J Ethnopharmacol 2007; 111: 677-680
  • 14 Hsieh CL, Cheng CY, Tsai TH, Lin IH, Liu CH, Chiang SY, Lin JG, Lao CJ, Tang NY. Paeonol reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats. J Ethnopharmacol 2006; 106: 208-215
  • 15 Li DQ, Bao YM, Zhao JJ, Liu CP, Liu Y, An LJ. Neuroprotective properties of catalpol in transient global cerebral ischemia in gerbils: dose-response, therapeutic time-window long-term efficacy. Brain Res 2004; 1029: 179-185
  • 16 Lim MY, Park YH, Kim MK, Lee HS. Antiplatelet activity of gallic acid and methyl gallate. Food Sci Biotechnol 2004; 13: 806-809
  • 17 Ou SY, Kwok KC. Ferulic acid: pharmaceutical functions, preparation and applications in foods. J Sci Food Agric 2004; 84: 1261-1269
  • 18 Wang S, Xin K, Ma D. Effects of ligustrazine on plasma platelet aggregation rate, thromboxane B2, 6-keto-prostaglandin F1 alpha and von Willebrandʼs factor in patients with acute onset of cor pulmonale. Chin J Integr Tradit West Med 1999; 19: 602-604
  • 19 Zhu M, Tang YP, Duan JA, Guo JM, Guo S, Su SL, Shang EX, Qian DW, Ding AW. Roles of paeoniflorin and senkyunolide I in Si Wu decoction on antiplatelet and anticoagulation activities. J Sep Sci 2010; 33: 3335-3340
  • 20 Zhan JYX, Zheng KYZ, Zhu KY, Bi CWC, Zhang WL, Du CYQ, Fu Q, Dong TTX, Choi RCY, Tsim KWK, Lau DTW. Chemical and biological assessment of Angelicae Sinensis Radix after processing with wine: an orthogonal array design to reveal the optimized conditions. J Agric Food Chem 2011; 59: 6091-6098
  • 21 Ashida SI, Abiko Y. Inhibition of platelet aggregation by a new agent, Ticlopidine. Thromb Haemost 1979; 40: 542-550
  • 22 Zhu TT, Choi RCY, Chu GKY, Cheung AWH, Gao QT, Li J, Jiang ZY, Dong TTX, Tsim KWK. Flavonoids possess neuroprotective effects on cultured pheochromocytoma PC12 cells: a comparison of different flavonoids in activating estrogenic effect and in preventing beta-amyloid-induced cell death. J Agric Food Chem 2007; 55: 2438-2445
  • 23 Ibbotson KJ, Harrod J, Gowen M, DʼSouza S, Smith DD, Winkler ME, Derynck R, Mundy GR. Human recombinant transforming growth factor alpha stimulates bone resorption and inhibits formation in vitro . Proc Natl Acad Sci USA 1986; 83: 2228-2232
  • 24 Guo AJY, Choi RCY, Cheung AWH, Chen VP, Xu SL, Dong TTX, Chen JJ, and Tsim KWK. Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/β-Catenin signaling pathway. J Biol Chem 2011; 286: 27882-27893
  • 25 Shao ML. Pharmacopoeia of the Peopleʼs Republic of China (Part I). Beijing: Chemical Industry Press; 2010: 124-125
  • 26 Yang L, Guo DQ, Yan B, Zhou WY, Huang YJ. The effects of ferulic acid on osteogenic differentiation and proliferation of bone marrow stromal stem cells: an experimental study. J Clin Exp Med 2009; 7: 6-8
  • 27 Liu YY, Zhao XX, Zhao HB. Tetramethylpyrazine induces the differentiation of mouse bone marrow-derived mesenchymal stem cells into nerve cells mediated by Ca2+ signaling. J Gansu Agric Univ 2010; 45: 5-9
  • 28 Du J, Bai B, Kuang X, Yu Y, Wang C, Ke Y, Xu Y, Tzang AHC, Qian ZM. Ligustilide inhibits spontaneous and agonists- or K+ depolarization-induced contraction of rat uterus. J Ethnopharmacol 2006; 108: 54-58
  • 29 Shi LF, Zheng XM, Cai Z, Wu BS. Comparison of influence of essential oil from Ligusticum chuanxiong Hort. on microcirculation in rabbit conjunctiva bulbar before and after decomposition of ligustilide. Chin J Pharmacol Toxicol 1995; 9: 157-158
  • 30 Yan S, Qiao GF. Effect of the oil of Angelica sinensis on contractial function of isolated uterine smooth muscle of mice. Chin Tradit Herb Drugs 2000; 31: 604-606